Corticosteroids are a class of
drugs that are closely related to cortisol, a steroid hormone produced in the
adrenal cortex. This medication is used to treat inflammatory diseases, such as
rheumatoid arthritis, juvenile arthritis, poison ivy, asthma, chronic
obstructive pulmonary disease (COPD), allergic rashes, Crohn's Disease, lupus,
polymyositis, scleroderma and vasculitis.
A recent study associated inhaled corticosteroids, which are primarily used to treat asthma and COPD, with the development and progression of diabetes mellitus. Patients on corticosteroid treatment experience a higher risk of developing type2 diabetes. Corticosteroids can induce insulin resistance and increase Glucagon secretion from the pancreas. The drug elevates the blood glucose levels, especially when taken for more than a few days.
Study Links Inhaled Corticosteroids with Elevated Risk ofDiabetes
A study conducted by researchers at the Lady Davis Institute of the Jewish General Hospital, Montreal, Quebec, and the McGill University, associated administration of inhaled corticosteroids with increased rate of diabetes progression and increased requirement for intensification ofdiabetes therapy.
The researchers examined the data of over 380,000 patients from the Quebec health insurance databases, who were treated for respiratory ailments (COPD or asthma). The participants were followed up for a period of five and a half years. It was observed that nearly 30,167 subjects developed diabetes and another 2,099 progressed from oral hypoglycemic therapy to insulin treatment during the follow-up period.
The researchers found that the inhaled corticosteroids can cause a 34% elevation in the rate of diabetes onset and diabetesprogression. Moreover, the highest inhaled doses can increase the risk of diabetes onset by 64% and diabetes progression by 54%.
The research findings are especially important for patients suffering from COPD because over 70% of the COPD patients use inhaled corticosteroids to fight their disease.
A recent study associated inhaled corticosteroids, which are primarily used to treat asthma and COPD, with the development and progression of diabetes mellitus. Patients on corticosteroid treatment experience a higher risk of developing type2 diabetes. Corticosteroids can induce insulin resistance and increase Glucagon secretion from the pancreas. The drug elevates the blood glucose levels, especially when taken for more than a few days.
Study Links Inhaled Corticosteroids with Elevated Risk ofDiabetes
A study conducted by researchers at the Lady Davis Institute of the Jewish General Hospital, Montreal, Quebec, and the McGill University, associated administration of inhaled corticosteroids with increased rate of diabetes progression and increased requirement for intensification ofdiabetes therapy.
The researchers examined the data of over 380,000 patients from the Quebec health insurance databases, who were treated for respiratory ailments (COPD or asthma). The participants were followed up for a period of five and a half years. It was observed that nearly 30,167 subjects developed diabetes and another 2,099 progressed from oral hypoglycemic therapy to insulin treatment during the follow-up period.
The researchers found that the inhaled corticosteroids can cause a 34% elevation in the rate of diabetes onset and diabetesprogression. Moreover, the highest inhaled doses can increase the risk of diabetes onset by 64% and diabetes progression by 54%.
The research findings are especially important for patients suffering from COPD because over 70% of the COPD patients use inhaled corticosteroids to fight their disease.
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